Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation.
Identifieur interne : 000585 ( Main/Exploration ); précédent : 000584; suivant : 000586Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantation.
Auteurs : Xavier Lévêque [France] ; Elodie Mathieux ; Véronique Nerrière-Daguin ; Reynald Thinard ; Laetitia Kermarrec ; Tony Durand ; Thomas Haudebourg ; Bernard Vanhove ; Laurent Lescaudron ; Isabelle Neveu ; Philippe NaveilhanSource :
- Journal of cellular and molecular medicine [ 1582-4934 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Antigens, CD11b (metabolism), Brain (immunology), Cell Survival, Chemokines (genetics), Chemokines (metabolism), Glial Fibrillary Acidic Protein (genetics), Glial Fibrillary Acidic Protein (metabolism), Graft Survival (immunology), Immunity, Immunity, Cellular, Immunocompetence, Male, Mesencephalon (cytology), Mesenchymal Stem Cell Transplantation, Mesenchymal Stromal Cells (cytology), Molecular Sequence Data, Motor Activity, Neurons (cytology), Neurons (metabolism), Neurons (transplantation), Oxidopamine, RNA, Messenger (genetics), RNA, Messenger (metabolism), Rats, Inbred Lew, Recovery of Function, Sus scrofa, Transplantation, Heterologous.
- MESH :
- chemical , genetics : Chemokines, Glial Fibrillary Acidic Protein, RNA, Messenger.
- chemical , metabolism : Antigens, CD11b, Chemokines, Glial Fibrillary Acidic Protein, RNA, Messenger.
- cytology : Mesencephalon, Mesenchymal Stromal Cells, Neurons.
- immunology : Brain, Graft Survival.
- metabolism : Neurons.
- transplantation : Neurons.
- Animals, Cell Survival, Immunity, Immunity, Cellular, Immunocompetence, Male, Mesenchymal Stem Cell Transplantation, Molecular Sequence Data, Motor Activity, Oxidopamine, Rats, Inbred Lew, Recovery of Function, Sus scrofa, Transplantation, Heterologous.
Abstract
Foetal pig neuroblasts are interesting candidates as a cell source for transplantation, but xenotransplantation in the brain requires the development of adapted immunosuppressive treatments. As systemic administration of high doses of cyclosporine A has side effects and does not protect xenotransplants forever, we focused our work on local control of the host immune responses. We studied the advantage of cotransplanting syngenic mesenchymal stem cells (MSC) with porcine neuroblasts (pNb) in immunocompetent rat striata. Two groups of animals were transplanted, either with pNb alone or with both MSC and pNb. At day 63, no porcine neurons were detected in the striata that received only pNb, while four of six rats transplanted with both pNb and MSC exhibited healthy porcine neurons. Interestingly, 50% of the cotransplanted rats displayed healthy grafts with pNF70+ and TH+ neurons at 120 days post-transplantation. qPCR analyses revealed a general dwindling of pro- and anti-inflammatory cytokines in the striata that received the cotransplants. Motor recovery was also observed following the transplantation of pNb and MSC in a rat model of Parkinson's disease. Taken together, the present data indicate that the immunosuppressive properties of MSC are of great interest for the long-term survival of xenogeneic neurons in the brain.
DOI: 10.1111/jcmm.12414
PubMed: 25310920
Affiliations:
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last="Lévêque">Xavier Lévêque</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, UMR 1064, Nantes, France; CHU de Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France; Faculté de Médecine, Université de Nantes, LUNAM Université, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR 1064, Nantes, France; CHU de Nantes, Institut de Transplantation et de Recherche en Transplantation, ITERT, Nantes, France; Faculté de Médecine, Université de Nantes, LUNAM Université, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Mathieux, Elodie" sort="Mathieux, Elodie" uniqKey="Mathieux E" first="Elodie" last="Mathieux">Elodie Mathieux</name></author><author><name 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Heterologous</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Foetal pig neuroblasts are interesting candidates as a cell source for transplantation, but xenotransplantation in the brain requires the development of adapted immunosuppressive treatments. As systemic administration of high doses of cyclosporine A has side effects and does not protect xenotransplants forever, we focused our work on local control of the host immune responses. We studied the advantage of cotransplanting syngenic mesenchymal stem cells (MSC) with porcine neuroblasts (pNb) in immunocompetent rat striata. Two groups of animals were transplanted, either with pNb alone or with both MSC and pNb. At day 63, no porcine neurons were detected in the striata that received only pNb, while four of six rats transplanted with both pNb and MSC exhibited healthy porcine neurons. Interestingly, 50% of the cotransplanted rats displayed healthy grafts with pNF70+ and TH+ neurons at 120 days post-transplantation. qPCR analyses revealed a general dwindling of pro- and anti-inflammatory cytokines in the striata that received the cotransplants. Motor recovery was also observed following the transplantation of pNb and MSC in a rat model of Parkinson's disease. Taken together, the present data indicate that the immunosuppressive properties of MSC are of great interest for the long-term survival of xenogeneic neurons in the brain.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement><orgName><li>Université de Nantes</li></orgName></list><tree><noCountry><name sortKey="Durand, Tony" sort="Durand, Tony" uniqKey="Durand T" first="Tony" last="Durand">Tony Durand</name><name sortKey="Haudebourg, Thomas" sort="Haudebourg, Thomas" uniqKey="Haudebourg T" first="Thomas" last="Haudebourg">Thomas Haudebourg</name><name sortKey="Kermarrec, Laetitia" sort="Kermarrec, Laetitia" uniqKey="Kermarrec L" first="Laetitia" last="Kermarrec">Laetitia Kermarrec</name><name sortKey="Lescaudron, Laurent" sort="Lescaudron, Laurent" uniqKey="Lescaudron L" first="Laurent" last="Lescaudron">Laurent Lescaudron</name><name sortKey="Mathieux, Elodie" sort="Mathieux, Elodie" uniqKey="Mathieux E" first="Elodie" last="Mathieux">Elodie Mathieux</name><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name><name sortKey="Nerriere Daguin, Veronique" sort="Nerriere Daguin, Veronique" uniqKey="Nerriere Daguin V" first="Véronique" last="Nerrière-Daguin">Véronique Nerrière-Daguin</name><name sortKey="Neveu, Isabelle" sort="Neveu, Isabelle" uniqKey="Neveu I" first="Isabelle" last="Neveu">Isabelle Neveu</name><name sortKey="Thinard, Reynald" sort="Thinard, Reynald" uniqKey="Thinard R" first="Reynald" last="Thinard">Reynald Thinard</name><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name></noCountry><country name="France"><region name="Pays de la Loire"><name sortKey="Leveque, Xavier" sort="Leveque, Xavier" uniqKey="Leveque X" first="Xavier" last="Lévêque">Xavier Lévêque</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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